Predictive Factors for the Benefit of Perioperative FOLFOX for Resectable Liver Metastasis in Colorectal Cancer Patients (EORTC Intergroup Trial 40983)
Identifieur interne : 005989 ( Main/Exploration ); précédent : 005988; suivant : 005990Predictive Factors for the Benefit of Perioperative FOLFOX for Resectable Liver Metastasis in Colorectal Cancer Patients (EORTC Intergroup Trial 40983)
Auteurs : Halfdan Sorbye [Norvège] ; Murielle Mauer [Belgique] ; Thomas Gruenberger [Autriche] ; Bengt Glimelius [Suède] ; Graeme J. Poston [Royaume-Uni] ; Peter M. Schlag [Allemagne] ; Philippe Rougier [France] ; Wolf O. Bechstein [Allemagne] ; John N. Primrose [Royaume-Uni] ; Euan T. Walpole [Australie] ; Meg Finch-Jones [Royaume-Uni] ; Daniel Jaeck [France] ; Darius Mirza [Royaume-Uni] ; Rowan W. Parks [Royaume-Uni] ; Laurence Collette [Belgique] ; Eric Van Cutsem [Belgique] ; Werner Scheithauer ; Manfred P. Lutz [Allemagne] ; Bernard Nordlinger [France]Source :
- Annals of surgery [ 0003-4932 ] ; 2012.
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- Pascal (Inist)
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English descriptors
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Abstract
Objective: In EORTC study 40983, perioperative FOLFOX increased progression-free survival (PFS) compared with surgery alone for patients with initially 1 to 4 resectable liver metastases from colorectal cancer (CRC). We conducted an exploratory retrospective analysis to identify baseline factors possibly predictive for a benefit of perioperative FOLFOX on PFS. Methods: The analysis was based on 237 events from 342 eligible patients. Cox proportional hazards regression models with a significance level of 0.1 were used to build up univariate and multivariate models. Results: After adjustment for identified prognostic factors, moderately (5.1- 30 ng/mL) and highly (> 30 ng/mL) elevated carcinoembryonic antigen (CEA) serum levels were both predictive for the benefit of perioperative chemotherapy (interaction P = 0.07; hazard ratio [HR] = 0.58 and HR = 0.52 for treatment benefit). For patients with moderately or highly elevated CEA (>5 ng/mL), the 3-year PFS was 35% with perioperative chemotherapy compared to 20% with surgery alone. Performance status (PS) 0 and BMI lower than 30 were also predictive for the benefit of perioperative chemotherapy (interaction P = 0.04 and P = 0.02). However, the number of patients with PS1 and BMI 30 or higher were limited. The benefit of perioperative therapy was not influenced by the number of metastatic lesions (1 vs 2-4, interaction HR = 0.98). Conclusions: Perioperative FOLFOX seems to benefit in particular patients with resectable liver metastases from CRC when CEA is elevated and when PS is unaffected, regardless of the number of metastatic lesions.
Affiliations:
- Allemagne, Australie, Autriche, Belgique, France, Norvège, Royaume-Uni, Suède
- Alsace (région administrative), Angleterre, Berlin, District de Darmstadt, East Middle Sweden, Grand Est, Hesse (Land), Midlands de l'Ouest, Région de Bruxelles-Capitale, Svealand, Vienne (Autriche), Écosse, Île-de-France
- Berlin, Birmingham, Boulogne-Billancourt, Bruxelles, Francfort-sur-le-Main, Stockholm, Strasbourg, Uppsala, Vienne (Autriche), Édimbourg
- Université d'Uppsala
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Lutz</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Caritasklinik St Theresa, Medical Department</s1><s2>Saarbrucken</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Saarbrucken</wicri:noRegion><wicri:noRegion>Medical Department</wicri:noRegion><wicri:noRegion>Saarbrucken</wicri:noRegion></affiliation></author><author><name sortKey="Nordlinger, Bernard" sort="Nordlinger, Bernard" uniqKey="Nordlinger B" first="Bernard" last="Nordlinger">Bernard Nordlinger</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre Hospitalier Universitaire Ambroise Pare, Assistance Publique Hôpitaux de Paris, Departments of Surgery and Oncology</s1><s2>Boulogne-Billancourt</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0199128</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0199128 INIST</idno><idno type="RBID">Pascal:12-0199128</idno><idno type="wicri:Area/PascalFrancis/Corpus">001414</idno><idno type="wicri:Area/PascalFrancis/Curation">004A99</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E46</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E46</idno><idno type="wicri:doubleKey">0003-4932:2012:Sorbye H:predictive:factors:for</idno><idno type="wicri:Area/Main/Merge">005C81</idno><idno type="wicri:Area/Main/Curation">005989</idno><idno type="wicri:Area/Main/Exploration">005989</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Predictive Factors for the Benefit of Perioperative FOLFOX for Resectable Liver Metastasis in Colorectal Cancer Patients (EORTC Intergroup Trial 40983)</title><author><name sortKey="Sorbye, Halfdan" sort="Sorbye, Halfdan" uniqKey="Sorbye H" first="Halfdan" last="Sorbye">Halfdan Sorbye</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Haukeland University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Mauer, Murielle" sort="Mauer, Murielle" uniqKey="Mauer M" first="Murielle" last="Mauer">Murielle Mauer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EORTC Headquarters, Statistics Department</s1><s2>Brussels</s2><s3>BEL</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Gruenberger, Thomas" sort="Gruenberger, Thomas" uniqKey="Gruenberger T" first="Thomas" last="Gruenberger">Thomas Gruenberger</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Medical University Vienna, Department of Internal Medicine I and Cancer Center and Department of General Surgery</s1><s2>Vienna</s2><s3>AUT</s3><sZ>3 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Radiology, Oncology and Radiation Science, Uppsala University</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName><orgName type="university">Université d'Uppsala</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Oncology and Pathology, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Poston, Graeme J" sort="Poston, Graeme J" uniqKey="Poston G" first="Graeme J." last="Poston">Graeme J. Poston</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Hospital Aintree</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University Hospital Aintree</wicri:noRegion></affiliation></author><author><name sortKey="Schlag, Peter M" sort="Schlag, Peter M" uniqKey="Schlag P" first="Peter M." last="Schlag">Peter M. Schlag</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Robert-Roessle-Klinik, Humboldt-Universitat Berlin, Surgery Department</s1><s2>Berlin</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Rougier, Philippe" sort="Rougier, Philippe" uniqKey="Rougier P" first="Philippe" last="Rougier">Philippe Rougier</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre Hospitalier Universitaire Ambroise Pare, Assistance Publique Hôpitaux de Paris, Departments of Surgery and Oncology</s1><s2>Boulogne-Billancourt</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author><author><name sortKey="Bechstein, Wolf O" sort="Bechstein, Wolf O" uniqKey="Bechstein W" first="Wolf O." last="Bechstein">Wolf O. Bechstein</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Klinikum der Johann-Wolfgang-Goethe-Universität, Department of General and Vascular Surgery</s1><s2>Frankfurt am Main</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Primrose, John N" sort="Primrose, John N" uniqKey="Primrose J" first="John N." last="Primrose">John N. Primrose</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University Department of Surgery, Southampton General Hospital</s1><s2>Southampton</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Walpole, Euan T" sort="Walpole, Euan T" uniqKey="Walpole E" first="Euan T." last="Walpole">Euan T. Walpole</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Princess Alexandra Hospital-University of Queensland, Woolloongabba, Brisbane</s1><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Princess Alexandra Hospital-University of Queensland, Woolloongabba, Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Finch Jones, Meg" sort="Finch Jones, Meg" uniqKey="Finch Jones M" first="Meg" last="Finch-Jones">Meg Finch-Jones</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Bristol Royal Infirmary</s1><s2>Bristol</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol Royal Infirmary</wicri:noRegion></affiliation></author><author><name sortKey="Jaeck, Daniel" sort="Jaeck, Daniel" uniqKey="Jaeck D" first="Daniel" last="Jaeck">Daniel Jaeck</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Hopital Universitaire Hautepierre</s1><s2>Strasbourg</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Mirza, Darius" sort="Mirza, Darius" uniqKey="Mirza D" first="Darius" last="Mirza">Darius Mirza</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>University Hospital Birmingham</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Parks, Rowan W" sort="Parks, Rowan W" uniqKey="Parks R" first="Rowan W." last="Parks">Rowan W. Parks</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Royal Infirmary of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Collette, Laurence" sort="Collette, Laurence" uniqKey="Collette L" first="Laurence" last="Collette">Laurence Collette</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EORTC Headquarters, Statistics Department</s1><s2>Brussels</s2><s3>BEL</s3><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Van Cutsem, Eric" sort="Van Cutsem, Eric" uniqKey="Van Cutsem E" first="Eric" last="Van Cutsem">Eric Van Cutsem</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University Hospital Gasthuisberg, Digestive Oncology Unit</s1><s2>Leuven</s2><s3>BEL</s3><sZ>16 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Scheithauer, Werner" sort="Scheithauer, Werner" uniqKey="Scheithauer W" first="Werner" last="Scheithauer">Werner Scheithauer</name><affiliation><inist:fA14 i1="17"><s1>Department of Internal Medicine I & Comprehensive Cancer Center</s1><s3>INC</s3><sZ>17 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation></author><author><name sortKey="Lutz, Manfred P" sort="Lutz, Manfred P" uniqKey="Lutz M" first="Manfred P." last="Lutz">Manfred P. Lutz</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Caritasklinik St Theresa, Medical Department</s1><s2>Saarbrucken</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Saarbrucken</wicri:noRegion><wicri:noRegion>Medical Department</wicri:noRegion><wicri:noRegion>Saarbrucken</wicri:noRegion></affiliation></author><author><name sortKey="Nordlinger, Bernard" sort="Nordlinger, Bernard" uniqKey="Nordlinger B" first="Bernard" last="Nordlinger">Bernard Nordlinger</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre Hospitalier Universitaire Ambroise Pare, Assistance Publique Hôpitaux de Paris, Departments of Surgery and Oncology</s1><s2>Boulogne-Billancourt</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Annals of surgery</title><title level="j" type="abbreviated">Ann. surg.</title><idno type="ISSN">0003-4932</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of surgery</title><title level="j" type="abbreviated">Ann. surg.</title><idno type="ISSN">0003-4932</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term><term>Colorectal cancer</term><term>Efficiency</term><term>European Organization for Research and Treatment of Cancer</term><term>Human</term><term>Liver cancer</term><term>Liver metastasis</term><term>Medicine</term><term>Patient</term><term>Perioperative</term><term>Predictive factor</term><term>Surgery</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer du foie</term><term>Facteur prédictif</term><term>Efficacité</term><term>Métastase foie</term><term>Périopératoire</term><term>Homme</term><term>Cancer colorectal</term><term>Malade</term><term>Essai clinique</term><term>Médecine</term><term>Chirurgie</term><term>Traitement</term><term>EORTC</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Médecine</term><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: In EORTC study 40983, perioperative FOLFOX increased progression-free survival (PFS) compared with surgery alone for patients with initially 1 to 4 resectable liver metastases from colorectal cancer (CRC). We conducted an exploratory retrospective analysis to identify baseline factors possibly predictive for a benefit of perioperative FOLFOX on PFS. Methods: The analysis was based on 237 events from 342 eligible patients. Cox proportional hazards regression models with a significance level of 0.1 were used to build up univariate and multivariate models. Results: After adjustment for identified prognostic factors, moderately (5.1- 30 ng/mL) and highly (> 30 ng/mL) elevated carcinoembryonic antigen (CEA) serum levels were both predictive for the benefit of perioperative chemotherapy (interaction P = 0.07; hazard ratio [HR] = 0.58 and HR = 0.52 for treatment benefit). For patients with moderately or highly elevated CEA (>5 ng/mL), the 3-year PFS was 35% with perioperative chemotherapy compared to 20% with surgery alone. Performance status (PS) 0 and BMI lower than 30 were also predictive for the benefit of perioperative chemotherapy (interaction P = 0.04 and P = 0.02). However, the number of patients with PS1 and BMI 30 or higher were limited. The benefit of perioperative therapy was not influenced by the number of metastatic lesions (1 vs 2-4, interaction HR = 0.98). Conclusions: Perioperative FOLFOX seems to benefit in particular patients with resectable liver metastases from CRC when CEA is elevated and when PS is unaffected, regardless of the number of metastatic lesions.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>France</li><li>Norvège</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Alsace (région administrative)</li><li>Angleterre</li><li>Berlin</li><li>District de Darmstadt</li><li>East Middle Sweden</li><li>Grand Est</li><li>Hesse (Land)</li><li>Midlands de l'Ouest</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li><li>Vienne (Autriche)</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Birmingham</li><li>Boulogne-Billancourt</li><li>Bruxelles</li><li>Francfort-sur-le-Main</li><li>Stockholm</li><li>Strasbourg</li><li>Uppsala</li><li>Vienne (Autriche)</li><li>Édimbourg</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><noCountry><name sortKey="Scheithauer, Werner" sort="Scheithauer, Werner" uniqKey="Scheithauer W" first="Werner" last="Scheithauer">Werner Scheithauer</name></noCountry><country name="Norvège"><noRegion><name sortKey="Sorbye, Halfdan" sort="Sorbye, Halfdan" uniqKey="Sorbye H" first="Halfdan" last="Sorbye">Halfdan Sorbye</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Mauer, Murielle" sort="Mauer, Murielle" uniqKey="Mauer M" first="Murielle" last="Mauer">Murielle Mauer</name></region><name sortKey="Collette, Laurence" sort="Collette, Laurence" uniqKey="Collette L" first="Laurence" last="Collette">Laurence Collette</name><name sortKey="Van Cutsem, Eric" sort="Van Cutsem, Eric" uniqKey="Van Cutsem E" first="Eric" last="Van Cutsem">Eric Van Cutsem</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Gruenberger, Thomas" sort="Gruenberger, Thomas" uniqKey="Gruenberger T" first="Thomas" last="Gruenberger">Thomas Gruenberger</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name></region><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Poston, Graeme J" sort="Poston, Graeme J" uniqKey="Poston G" first="Graeme J." last="Poston">Graeme J. Poston</name></noRegion><name sortKey="Finch Jones, Meg" sort="Finch Jones, Meg" uniqKey="Finch Jones M" first="Meg" last="Finch-Jones">Meg Finch-Jones</name><name sortKey="Mirza, Darius" sort="Mirza, Darius" uniqKey="Mirza D" first="Darius" last="Mirza">Darius Mirza</name><name sortKey="Parks, Rowan W" sort="Parks, Rowan W" uniqKey="Parks R" first="Rowan W." last="Parks">Rowan W. Parks</name><name sortKey="Primrose, John N" sort="Primrose, John N" uniqKey="Primrose J" first="John N." last="Primrose">John N. Primrose</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Schlag, Peter M" sort="Schlag, Peter M" uniqKey="Schlag P" first="Peter M." last="Schlag">Peter M. Schlag</name></region><name sortKey="Bechstein, Wolf O" sort="Bechstein, Wolf O" uniqKey="Bechstein W" first="Wolf O." last="Bechstein">Wolf O. Bechstein</name><name sortKey="Lutz, Manfred P" sort="Lutz, Manfred P" uniqKey="Lutz M" first="Manfred P." last="Lutz">Manfred P. Lutz</name></country><country name="France"><region name="Île-de-France"><name sortKey="Rougier, Philippe" sort="Rougier, Philippe" uniqKey="Rougier P" first="Philippe" last="Rougier">Philippe Rougier</name></region><name sortKey="Jaeck, Daniel" sort="Jaeck, Daniel" uniqKey="Jaeck D" first="Daniel" last="Jaeck">Daniel Jaeck</name><name sortKey="Nordlinger, Bernard" sort="Nordlinger, Bernard" uniqKey="Nordlinger B" first="Bernard" last="Nordlinger">Bernard Nordlinger</name></country><country name="Australie"><noRegion><name sortKey="Walpole, Euan T" sort="Walpole, Euan T" uniqKey="Walpole E" first="Euan T." last="Walpole">Euan T. Walpole</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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